Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.60 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.57 |
| ▸ | ITGAV | P06756 | 3/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049969 | 0.84 | ADAM17 (0.44) | KDM4EALOX15TSHRSIRT1ITGB3 | |
| SCHEMBL6440847 | 0.82 | ADAM17 (0.51) | KDM4EADAM17ALDH1A1PRMT5WDR77 | |
| SCHEMBL8547905 | 0.79 | ADAM17 (0.53) | KDM4EADAM17ALDH1A1PRMT5WDR77 | |
| SCHEMBL15776135 | 0.78 | ADAM17 (0.44) | KDM4EALOX15TSHRSIRT1ITGB3 | |
| SCHEMBL1002943 | 0.77 | ADAM17 (0.57) | KDM4EADAM17ALDH1A1PRMT5WDR77 | |
| SCHEMBL22446339 | 0.77 | HDAC6 (0.45) | ADAM17AOC3 | |
| SCHEMBL7788827 | 0.76 | ITGB3 (0.69) | ITGB3ITGA2BAOC3 | |
| SCHEMBL15169553 | 0.76 | METAP1 (0.45) | KDM4EADAM17ALDH1A1HPGDPRMT5 | |
| SCHEMBL22713735 | 0.76 | AOC3 (0.69) | ITGB3ITGAVITGA2BPRMT5WDR77 | |
| SCHEMBL315339 | 0.76 | KDM4E (1.00) | KDM4EALOX15TSHRSIRT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007001249-A1 | NITROGEN HETEROCYCLE BIARYLS FOR OSTEOPOROSIS AND OTHER DISEASES | PHARMACOPEIA, INC. (US) | 2007-01-04 | — | — | WO | disclosed |