Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.53 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | PHGDH | O43175 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4761009 | 0.83 | MEN1 (0.56) | HTTMAPTSMN1; SMN2NPSR1CYP3A4 | |
| SCHEMBL4719711 | 0.80 | KMT2A (0.73) | HTTMAPTSMN1; SMN2NPSR1GAA | |
| SCHEMBL4320008 | 0.77 | LOXL2 (0.59) | LMNAMAPK1 | |
| SCHEMBL30883140 | 0.77 | SERPINE1 (0.61) | HTTMAPTSMN1; SMN2NPSR1KMT2A | |
| SCHEMBL4762716 | 0.76 | SMN1; SMN2 (0.51) | HTTMAPTSMN1; SMN2NPSR1CYP3A4 | |
| SCHEMBL18983674 | 0.74 | KMT2A (0.70) | HTTMAPTSMN1; SMN2NPSR1CYP3A4 | |
| SCHEMBL912369 | 0.74 | MAPT (0.55) | HTTMAPTSMN1; SMN2NPSR1CYP3A4 | |
| SCHEMBL28087592 | 0.73 | ALDH1A1 (0.47) | HTTMAPTSMN1; SMN2NPSR1GAA | |
| SCHEMBL8249882 | 0.73 | KMT2A (0.57) | HTTMAPTSMN1; SMN2NPSR1GAA | |
| SCHEMBL9639996 | 0.73 | KMT2A (0.69) | HTTSMN1; SMN2NPSR1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007009635-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |