Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RUVBL1 | Q9Y265 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | MPO | P05164 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | AKT1 | P31749 | 2/20 | 0.58 |
| ▸ | CDC7 | O00311 | 1/20 | 0.58 |
| ▸ | CHUK | O15111 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.58 |
| ▸ | PRKCG | P05129 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL19748758 | 0.94 | RUVBL1 (0.73) | RUVBL1KDM4ELMNAMAPTTSHR | |
| SCHEMBL30767397 | 0.91 | MEN1 (0.71) | RUVBL1KDM4ELMNAMAPTTSHR | |
| SCHEMBL9610738 | 0.91 | MEN1 (0.71) | RUVBL1KDM4ELMNAMAPTTSHR | |
| SCHEMBL9609465 | 0.91 | MEN1 (0.71) | RUVBL1KDM4ELMNAMAPTTSHR | |
| Hydrochloric Acid SCHEMBL19747056 | 0.90 | MEN1 (0.69) | RUVBL1KDM4ELMNAMAPTTSHR | |
| Hydrochloric Acid SCHEMBL21082966 | 0.90 | MEN1 (0.69) | RUVBL1KDM4ELMNAMAPTTSHR | |
| SCHEMBL6287113 | 0.89 | RUVBL1 (0.66) | RUVBL1KDM4ELMNAMAPTTSHR | |
| SCHEMBL6337317 | 0.89 | RUVBL1 (0.66) | RUVBL1KDM4ELMNAMAPTTSHR | |
| SCHEMBL7035663 | 0.89 | RUVBL1 (0.66) | RUVBL1KDM4ELMNAMAPTTSHR | |
| SCHEMBL11860142 | 0.88 | RUVBL1 (0.65) | RUVBL1KDM4ELMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919468-B2 | Compounds useful as modulators of the proteasome activity | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2011-04-05 | — | — | US | disclosed |
| US-7919468-B2 | Compounds useful as modulators of the proteasome activity | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2011-04-05 | — | — | US | disclosed |
| US-20090069222-A1 | Compounds Useful as Modulators of the Proteasome Activity | CENTRE NATIONAL DE AL RECHERCHE SCIENTIFIQUE (FR) | 2009-03-12 | — | — | US | disclosed |
| US-20090069222-A1 | Compounds Useful as Modulators of the Proteasome Activity | CENTRE NATIONAL DE AL RECHERCHE SCIENTIFIQUE (FR) | 2009-03-12 | — | — | US | disclosed |
| WO-2006105811-A1 | COMPOUNDS USEFUL AS MODULATORS OF THE PROTEASOME ACTIVITY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2006-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069222-A1 | Compounds Useful as Modulators of the Proteasome Activity | PSMB10, PSMB11, PSMB6 | RUVBL1 1409/4885KDM4E 2618/4885LMNA 2560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.