Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | FAP | Q12884 | 2/20 | 0.34 |
| ▸ | PITRM1 | Q5JRX3 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 8/20 | 0.34 |
| ▸ | CTSL | P07711 | 4/20 | 0.34 |
| ▸ | CTSK | P43235 | 4/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CELA1 | Q9UNI1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13249153 | 0.95 | DPP4 (0.33) | DPP4FAPPITRM1DPP8DPP9 | |
| SCHEMBL10274953 | 0.93 | CTSB (0.33) | DPP4FAPPITRM1DPP8DPP9 | |
| SCHEMBL14279155 | 0.91 | DPP4 (0.32) | DPP4FAPPITRM1DPP8DPP9 | |
| SCHEMBL8243653 | 0.89 | ABCG2 (0.35) | CTSBCTSLCTSKABCG2CTSV | |
| SCHEMBL8239967 | 0.89 | CTSB (0.34) | CTSBCTSLCTSKABCG2CTSV | |
| SCHEMBL10274956 | 0.88 | DPP4 (0.33) | DPP4FAPPITRM1DPP8DPP9 | |
| SCHEMBL14595896 | 0.88 | CTSV (0.40) | DPP4FAPPITRM1DPP8DPP9 | |
| SCHEMBL8249130 | 0.84 | ABCG2 (0.32) | CTSBCTSLCTSKABCG2CTSV | |
| SCHEMBL8279718 | 0.84 | CTSB (0.33) | CTSBCTSLCTSKCTSVELANE | |
| SCHEMBL10274946 | 0.84 | DPP4 (0.32) | DPP4FAPPITRM1DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342041-B2 | 3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis C virus NS3 serine protease | SCHERING CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |
| WO-2006130687-A2 | LIVER/PLASMA CONCENTRATION RATIO FOR DOSING HEPATITIS C VIRUS PROTEASE INHIBITOR | SCHERING CORPORATION (US) | 2006-12-07 | — | — | WO | disclosed |