Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD51 | Q06609 | 2/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | IDE | P14735 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18229960 | 0.85 | TRPV4 (0.43) | RAD51TRPV4L3MBTL1PTGS2CA1 | |
| SCHEMBL3778124 | 0.83 | CA1 (0.47) | RAD51TRPV4CA1CA2CA9 | |
| SCHEMBL20997500 | 0.82 | TRPV4 (0.44) | RAD51TRPV4CA1CA2CA9 | |
| SCHEMBL1755156 | 0.81 | RAD51 (0.44) | RAD51TRPV4CA1CA2CA9 | |
| SCHEMBL125367 | 0.79 | RAD51 (0.45) | RAD51TRPV4L3MBTL1PTGS2ALDH1A1 | |
| SCHEMBL10164103 | 0.79 | RAD51 (0.45) | RAD51TRPV4PTGS2ALDH1A1CASP3 | |
| SCHEMBL12560333 | 0.78 | VCAM1 (0.46) | RAD51TRPV4PTGS2EPAS1 | |
| SCHEMBL15412234 | 0.78 | ACLY (0.49) | RAD51TRPV4PTGS2EPAS1 | |
| SCHEMBL15411080 | 0.77 | RAD51 (0.41) | RAD51TRPV4CA1CA2CA9 | |
| SCHEMBL18469731 | 0.76 | TRPV4 (0.45) | RAD51TRPV4L3MBTL1PTGS2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174862-B1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2019-10-23 | — | — | EP | disclosed |
| WO-2006128184-A2 | PYRIMIDINE OR TRIAZINE FUSED BICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS-PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| US-4053465-A | CYANOPHENYL-AZO-AMINOPHENYL DYESTUFFS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-10-11 | — | — | US | disclosed |