SCHEMBL8256288

SCHEMBL8256288

Cc1nc(C(=O)Nc2ccc(N3CCOC3=N)cc2)c(C(=O)Nc2ccc(Cl)cn2)s1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F10 P00742 7/20 0.44
F2 P00734 1/20 0.42
KLKB1 P03952 1/20 0.41
RAB9A P51151 7/20 0.39
SMN1; SMN2 Q16637 4/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
MAPK1 P28482 2/20 0.39
NPC1 O15118 5/20 0.38
TP53 P04637 2/20 0.38
TSHR P16473 2/20 0.38
NFKB1 P19838 1/20 0.38
NFKB2 Q00653 1/20 0.38
RELA Q04206 1/20 0.38
TRPV4 Q9HBA0 1/20 0.38
NAMPT P43490 1/20 0.37
KDM4E B2RXH2 1/20 0.37
HTT P42858 2/20 0.37
MITF O75030 1/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8258622 1.00 F10 (0.44) F10F2KLKB1RAB9ASMN1; SMN2
SCHEMBL4884938 0.97 F10 (0.42) F10F2KLKB1RAB9ASMN1; SMN2
SCHEMBL4878211 0.85 F10 (0.47) F10F2KLKB1RAB9ASMN1; SMN2
Hydrochloric Acid SCHEMBL4886675 0.84 F10 (0.46) F10F2KLKB1RAB9ASMN1; SMN2
Bromide SCHEMBL4885344 0.84 F10 (0.46) F10F2KLKB1RAB9ASMN1; SMN2
SCHEMBL4884191 0.82 F10 (0.45) F10F2KLKB1RAB9ASMN1; SMN2
SCHEMBL5229206 0.82 F2 (0.39) F10F2KLKB1RAB9ASMN1; SMN2
SCHEMBL8260892 0.82 F2 (0.49) F10F2KLKB1RAB9ASMN1; SMN2
SCHEMBL5237784 0.82 F2 (0.49) F10F2KLKB1RAB9ASMN1; SMN2
SCHEMBL5229415 0.81 ALDH1A1 (0.34) F10F2RAB9ASMN1; SMN2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080214533-A1 Cyclic Iminocarbamates And Their Use BAYER HEALTHCARE AG (DE) 2008-09-04 US disclosed
US-20080214533-A1 Cyclic Iminocarbamates And Their Use BAYER HEALTHCARE AG (DE) 2008-09-04 US disclosed
WO-2006058630-A1 CYCLIC IMINOCARBAMATES AND USE THEREOF BAYER HEALTHCARE AG (DE) 2006-06-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080214533-A1 Cyclic Iminocarbamates And Their Use F2, UQCRB, F12 F10 26/4885F2 1/4885KLKB1 2528/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.