Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 8/20 | 0.51 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.46 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.46 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550933 | 0.94 | IL2 (0.56) | IL2ORAI1STIM1ORAI2KMT2A | |
| SCHEMBL5550953 | 0.86 | IL2 (0.66) | IL2ORAI1STIM1ORAI2KMT2A | |
| SCHEMBL15395991 | 0.86 | IL2 (0.56) | IL2ORAI1STIM1ORAI2KMT2A | |
| SCHEMBL5550956 | 0.83 | ORAI1 (0.67) | IL2ORAI1STIM1KMT2ANPC1 | |
| SCHEMBL5550650 | 0.82 | ORAI1 (0.52) | IL2ORAI1STIM1KMT2ANPC1 | |
| SCHEMBL8258488 | 0.78 | IL2 (0.47) | IL2ORAI1STIM1ORAI2KMT2A | |
| SCHEMBL8257494 | 0.78 | IL2 (0.66) | IL2ORAI1STIM1ORAI2KMT2A | |
| SCHEMBL8260166 | 0.76 | ALDH1A1 (0.47) | IL2KMT2ANPC1ADORA3MEN1 | |
| SCHEMBL8252237 | 0.75 | IL2 (0.56) | IL2ORAI1STIM1ORAI2 | |
| SCHEMBL15395954 | 0.75 | ORAI1 (0.54) | IL2ORAI1STIM1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081391-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |