Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 12/20 | 0.47 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.47 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.47 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550482 | 0.94 | IL2 (0.47) | IL2STIM1ORAI1ORAI2CYP2C9 | |
| SCHEMBL8257121 | 0.87 | STIM1 (0.61) | IL2STIM1ORAI1ORAI2ALDH1A1 | |
| SCHEMBL5556022 | 0.85 | STIM1 (0.53) | IL2STIM1ORAI1ORAI2ALDH1A1 | |
| SCHEMBL15214058 | 0.85 | IL2 (0.50) | IL2STIM1ORAI1ORAI2ALDH1A1 | |
| SCHEMBL5550479 | 0.83 | IL2 (0.51) | IL2STIM1ORAI1ORAI2MEN1 | |
| SCHEMBL5554305 | 0.82 | IL2 (0.44) | IL2STIM1ORAI1ORAI2CYP2C19 | |
| SCHEMBL5556128 | 0.82 | IL2 (0.47) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL8257720 | 0.81 | IL2 (0.49) | IL2STIM1ORAI1ORAI2RAB9A | |
| SCHEMBL8257501 | 0.78 | IL2 (0.51) | IL2STIM1ORAI1ORAI2ALDH1A1 | |
| SCHEMBL15214056 | 0.76 | IL2 (0.54) | IL2STIM1ORAI1ORAI2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081391-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |