Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 15/20 | 0.66 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.66 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258128 | 0.81 | SIRT1 (0.63) | SIRT1SIRT2SIRT3SMN1; SMN2RECQL | |
| SCHEMBL1275557 | 0.80 | SIRT1 (1.00) | SIRT1SIRT2SIRT3ALOX15MEN1 | |
| SCHEMBL1870769 | 0.80 | SIRT1 (1.00) | SIRT1SIRT2SIRT3ALOX15MEN1 | |
| SCHEMBL1874310 | 0.80 | SIRT1 (1.00) | SIRT1SIRT2SIRT3ALOX15MEN1 | |
| Sulfuric Acid SCHEMBL8592514 | 0.77 | SIRT1 (0.57) | SIRT1SIRT2SIRT3SMN1; SMN2RECQL | |
| SCHEMBL8257650 | 0.76 | SIRT1 (1.00) | SIRT1SIRT2SIRT3ALOX15MEN1 | |
| SCHEMBL1873844 | 0.76 | SIRT1 (1.00) | SIRT1SIRT2SIRT3ALOX15MEN1 | |
| SCHEMBL8251110 | 0.76 | SIRT1 (1.00) | SIRT1SIRT2SIRT3ALOX15MEN1 | |
| SCHEMBL31328299 | 0.74 | SIRT1 (0.65) | SIRT1SIRT2SIRT3ALOX15MEN1 | |
| SCHEMBL30849292 | 0.74 | ADRA2A (0.49) | SIRT1SIRT2ALOX15KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677794-B1 | METHODS OF TREATING DISORDER | ELIXIR PHARMACEUTICALS INC (US) | 2014-12-03 | — | — | EP | disclosed |
| WO-2010054382-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATING MALARIA OR LEISHMANIASIS | ELIXIR PHARMACEUTICALS, INC. (US) | 2010-05-14 | — | — | WO | disclosed |
| WO-2008082646-A2 | HISTONE DEACETYLASE INHIBITORS, COMBINATION THERAPIES AND METHODS OF USE | THE JOHNS HOPKINS UNIVERSITY (US) | 2008-07-10 | — | — | WO | disclosed |
| WO-2006099245-A9 | SIRT INHIBITORS THAT BIND TO NAD | ELIXIR PHARMACEUTICALS INC (US) | 2006-11-09 | — | — | WO | disclosed |
| WO-2006099245-A1 | SIRT INHIBITORS THAT BIND TO NAD | ELIXIR PHARMACEUTICALS, INC. (US) | 2006-09-21 | — | — | WO | disclosed |
| WO-2006031894-A2 | METHODS OF TREATING A DISORDER | ELIXIR PHARMACEUTICALS, INC. (US) | 2006-03-23 | — | — | WO | disclosed |
| WO-2005072408-A2 | TREATING A VIRAL DISORDER | ELIXIR PHARMACEUTICALS, INC (US) | 2005-08-11 | — | — | WO | disclosed |
| WO-2005026112-A2 | METHODS OF TREATING A DISORDER | ELIXIR PHARMACEUTICALS, INC. (US) | 2005-03-24 | — | — | WO | disclosed |