Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8253899 | 0.86 | KDM4E (0.40) | LMNATDP1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8256657 | 0.74 | HPGD (0.44) | LMNATDP1ALDH1A1L3MBTL1HPGD | |
| SCHEMBL8258266 | 0.73 | LMNA (0.34) | LMNATDP1KDM4EL3MBTL1TSHR | |
| SCHEMBL8253920 | 0.73 | KDM4E (0.40) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL8256633 | 0.71 | KDM4E (0.40) | LMNATDP1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL8191599 | 0.70 | PIM1 (0.39) | KDM4EALDH1A1HPGDHSD17B10LCK | |
| SCHEMBL8253049 | 0.70 | ALDH1A1 (0.52) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8255673 | 0.69 | MEN1 (0.33) | LMNATDP1 | |
| SCHEMBL2273813 | 0.69 | AURKA (0.49) | KDM4EALDH1A1HPGDHSD17B10MAPK1 | |
| SCHEMBL8256619 | 0.69 | AURKA (0.46) | KDM4EALDH1A1L3MBTL1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006128184-A2 | PYRIMIDINE OR TRIAZINE FUSED BICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS-PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |