Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4318192 | 0.80 | GRM2 (0.57) | MEN1KMT2AGRM2DRD2DRD4 | |
| SCHEMBL2675769 | 0.74 | MEN1 (0.52) | MEN1KMT2AGRM2DRD2DRD4 | |
| SCHEMBL4318159 | 0.73 | ALDH1A1 (0.48) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL8255009 | 0.73 | ALDH1A1 (0.47) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL4244132 | 0.72 | MEN1 (0.56) | MEN1KMT2AGRM2DRD2DRD4 | |
| SCHEMBL5199448 | 0.71 | DRD2 (0.55) | MEN1KMT2AGRM2DRD2DRD4 | |
| SCHEMBL4166695 | 0.69 | MEN1 (0.60) | MEN1KMT2AGRM2DRD2DRD4 | |
| Bromide SCHEMBL4174809 | 0.69 | MEN1 (0.59) | MEN1KMT2AGRM2DRD2DRD4 | |
| SCHEMBL24606221 | 0.69 | GRM2 (1.00) | MEN1KMT2AGRM2DRD2DRD4 | |
| SCHEMBL29709278 | 0.69 | GRM2 (1.00) | MEN1KMT2AGRM2DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |