Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4320077 | 0.89 | GAA (0.50) | TSHRMAPTGAAALDH1A1ALOX15 | |
| SCHEMBL4318702 | 0.86 | KMT2A (0.51) | TSHRGAAALDH1A1ALOX15BCHE | |
| SCHEMBL29993 | 0.85 | ALDH1A1 (0.64) | TSHRKDM4EMAPTGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL28445202 | 0.84 | ALDH1A1 (0.62) | TSHRKDM4EMAPTGAAALDH1A1 | |
| SCHEMBL4321369 | 0.82 | FPR2 (0.49) | TSHRKDM4EMAPTGAAALDH1A1 | |
| SCHEMBL4322495 | 0.78 | BRD9 (0.45) | MAPTGAAALDH1A1ALOX15BCHE | |
| SCHEMBL23907007 | 0.78 | ALDH1A1 (0.46) | TSHRKDM4EMAPTUSP2GAA | |
| SCHEMBL6262072 | 0.78 | BCHE (0.74) | TSHRKDM4EMAPTUSP2GAA | |
| SCHEMBL14946541 | 0.75 | ALDH1A1 (0.47) | TSHRKDM4EMAPTUSP2GAA | |
| SCHEMBL13468170 | 0.74 | GAA (0.50) | TSHRMAPTGAAALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |