Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 7/20 | 0.71 |
| ▸ | CTSB | P07858 | 6/20 | 0.71 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.71 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.71 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.71 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.66 |
| ▸ | CTSK | P43235 | 3/20 | 0.66 |
| ▸ | CTSS | P25774 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2141126 | 1.00 | CTSL (0.71) | CTSLCTSBPSMB1PSMB5PSMB2 | |
| SCHEMBL23234553 | 0.99 | CTSL (0.73) | CTSLCTSBPSMB1PSMB5PSMB2 | |
| SCHEMBL8260303 | 0.99 | CTSL (0.73) | CTSLCTSBPSMB1PSMB5PSMB2 | |
| SCHEMBL2253238 | 0.99 | CTSL (0.73) | CTSLCTSBPSMB1PSMB5PSMB2 | |
| SCHEMBL14341576 | 0.99 | CTSL (0.73) | CTSLCTSBPSMB1PSMB5PSMB2 | |
| SCHEMBL7028808 | 0.95 | CTSL (0.68) | CTSLCTSBPSMB1PSMB5PSMB2 | |
| SCHEMBL7028811 | 0.95 | CTSL (0.68) | CTSLCTSBPSMB1PSMB5PSMB2 | |
| Mg-132 SCHEMBL13436259 | 0.93 | PSMB1 (0.77) | CTSLCTSBPSMB1PSMB5PSMB2 | |
| Mg-132 SCHEMBL14579851 | 0.93 | PSMB1 (0.77) | CTSLCTSBPSMB1PSMB5PSMB2 | |
| Mg-132 SCHEMBL14514061 | 0.93 | PSMB1 (0.77) | CTSLCTSBPSMB1PSMB5PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589066-B2 | Such as N-carbobenzyloxy-phenylalanyl-phenylalanylal; for treating cancer, inflammation, and/or autoimmune diseases; suppresses endogenous antigenic peptide generation | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2009-09-15 | — | — | US | disclosed |
| WO-2006099261-A2 | POTENT AND SPECIFIC IMMUNOPROTEASOME INHIBITORS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-09-21 | — | — | WO | disclosed |