Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 5/20 | 0.33 |
| ▸ | HTR1B | P28222 | 4/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8255692 | 0.85 | HTR1A (0.47) | HTR1ADRD2SIGMAR1KMT2AMEN1 | |
| SCHEMBL8253225 | 0.78 | DRD2 (0.60) | HTR1ADRD2KMT2AMEN1PSMD14 | |
| SCHEMBL8246237 | 0.76 | DRD2 (0.55) | HTR1ADRD2HTR1DHTR1BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL5458668 | 0.75 | HTR1A (0.54) | HTR1ADRD2HTR1DHTR1BSIGMAR1 | |
| SCHEMBL13533092 | 0.74 | HTR1A (0.65) | HTR1ADRD2 | |
| SCHEMBL8258255 | 0.74 | DRD2 (0.47) | HTR1ADRD2SLC6A4 | |
| SCHEMBL13681603 | 0.70 | HTR1A (0.41) | HTR1ADRD2ASAH1JAK2BTK | |
| SCHEMBL17776035 | 0.69 | ASAH1 (0.48) | HTR1ADRD2LMNAASAH1JAK2 | |
| SCHEMBL14867215 | 0.69 | ASAH1 (0.42) | HTR1ADRD2KMT2AMEN1LMNA | |
| SCHEMBL5546415 | 0.67 | JAK2 (0.42) | HTR1ADRD2KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006061379-A1 | PHENYLPIPERAZINE DERIVATIVES WITH A COMBINATION OF PARTIAL DOPAMINE-D2 RECEPTOR AGONISM AND SEROTONIN REUPTAKE INHIBITION | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-06-15 | — | — | WO | disclosed |