Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BPTF | Q12830 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2993170 | 0.87 | CYP19A1 (0.55) | CYP19A1MEN1KMT2ARAB9ABPTF | |
| SCHEMBL11510712 | 0.84 | HDAC4 (0.54) | HDAC4MEF2DCYP19A1MEN1KMT2A | |
| SCHEMBL17266296 | 0.84 | MAOA (0.57) | HDAC4MEF2DMEN1KMT2ARAB9A | |
| SCHEMBL11248387 | 0.82 | MAOA (0.48) | CYP19A1MEN1KMT2ABPTFALDH1A1 | |
| Hydrochloric Acid SCHEMBL11247111 | 0.80 | MAOA (0.50) | CYP19A1MEN1KMT2ABPTFMAPT | |
| Hydrochloric Acid SCHEMBL11247122 | 0.80 | MAOA (0.50) | CYP19A1MEN1KMT2ABPTFMAPT | |
| SCHEMBL5153716 | 0.80 | MAOA (0.49) | CYP19A1MEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL6755669 | 0.79 | ADRA2B (0.54) | CYP19A1BPTFMAOAMAOB | |
| SCHEMBL5846731 | 0.79 | MAOA (0.43) | CYP19A1BPTFMAOAMAOB | |
| SCHEMBL13812986 | 0.79 | MAPT (0.59) | MEN1KMT2ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006066896-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2006-06-29 | — | — | WO | disclosed |