Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 4/20 | 0.44 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.44 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14160901 | 0.80 | SLC6A4 (0.43) | PDK1MEP1AMEP1BSLC6A4SLC6A2 | |
| SCHEMBL153971 | 0.77 | MEP1A (0.53) | MRGPRX4PDK1MEP1AMEP1BSLC6A4 | |
| SCHEMBL8263076 | 0.76 | NR1H2 (0.54) | CNR1NR3C1 | |
| SCHEMBL25489322 | 0.75 | MEP1A (0.48) | MRGPRX4PDK1MEP1AMEP1BSLC6A4 | |
| SCHEMBL17454810 | 0.74 | AOC3 (0.52) | MRGPRX4PDK1MEP1AMEP1BSLC6A4 | |
| SCHEMBL153227 | 0.74 | MEN1 (0.51) | NR3C1 | |
| SCHEMBL28733027 | 0.73 | MEP1B (0.64) | MRGPRX4MEP1AMEP1BSLC6A4SLC6A2 | |
| SCHEMBL21723955 | 0.73 | MEP1A (0.44) | MRGPRX4PDK1PSEN1PSEN2APH1B | |
| SCHEMBL150221 | 0.72 | MEP1A (0.48) | MRGPRX4PDK1MEP1AMEP1BSLC6A4 | |
| SCHEMBL151355 | 0.71 | MEP1A (0.50) | MRGPRX4MEP1AMEP1BSLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006066896-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2006-06-29 | — | — | WO | disclosed |