Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8260134 | 1.00 | SLC6A3 (0.46) | SLC6A3LMNAFAAHCYP3A4CYP2D6 | |
| SCHEMBL4462497 | 0.86 | EPHX2 (0.49) | SLC6A3LMNARAB9AHDAC6KCNH2 | |
| SCHEMBL4464693 | 0.86 | EPHX2 (0.49) | SLC6A3LMNARAB9AHDAC6KCNH2 | |
| SCHEMBL4462494 | 0.86 | EPHX2 (0.49) | SLC6A3LMNARAB9AHDAC6KCNH2 | |
| SCHEMBL13932368 | 0.82 | SLC6A3 (0.49) | SLC6A3LMNAFAAHCYP3A4CYP2D6 | |
| SCHEMBL4475958 | 0.82 | POLB (0.55) | SLC6A3RAB9AHDAC3HDAC1HDAC2 | |
| SCHEMBL4465482 | 0.82 | KCNH2 (0.43) | SLC6A3LMNAFAAHCYP3A4CYP2D6 | |
| SCHEMBL4462455 | 0.82 | POLB (0.55) | SLC6A3RAB9AHDAC3HDAC1HDAC2 | |
| SCHEMBL4465355 | 0.82 | SLC6A9 (0.50) | SLC6A3TBXA2RHDAC3HDAC1KCNH2 | |
| SCHEMBL4465361 | 0.82 | SLC6A9 (0.50) | SLC6A3TBXA2RHDAC3HDAC1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511077-B2 | Diamine calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-03-31 | — | — | US | disclosed |
| US-7511077-B2 | Diamine calcium channel blockers | NEUROMED PHARMACEUTICALS LTD. (CA) | 2009-03-31 | — | — | US | disclosed |
| WO-2006084369-A1 | DIAMINE CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2006-08-17 | — | — | WO | disclosed |