Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 5/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 5/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23601553 | 0.88 | TRIM24 (0.56) | FYNCLK4DYRK1BTRIM24PARP10 | |
| SCHEMBL21013242 | 0.86 | TRIM24 (0.46) | TRIM24BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL5986263 | 0.82 | HSD17B10 (0.47) | TRIM24BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL22643366 | 0.78 | TRIM24 (0.42) | TRIM24BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL29899555 | 0.77 | ACVRL1 (0.47) | TRIM24BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL23143545 | 0.77 | ACVRL1 (0.47) | TRIM24BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL21234046 | 0.74 | ASIC3 (0.43) | TRIM24BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL18828818 | 0.74 | CTSC (0.42) | TRIM24BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL19368465 | 0.72 | CTSC (0.48) | TRIM24BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL19155004 | 0.72 | CHRM1 (0.48) | TRIM24BMPR1BBMPR1AACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177518-A1 | Organic compounds | Novartis AG (CH) | 2010-04-21 | — | — | EP | disclosed |
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |