Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 16/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 16/20 | 0.47 |
| ▸ | BMPR1A | P36894 | 14/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 13/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29899555 | 1.00 | ACVRL1 (0.47) | ACVRL1ACVR1BMPR1ABMPR1BTRIM24 | |
| SCHEMBL21013242 | 0.84 | TRIM24 (0.46) | ACVRL1ACVR1BMPR1ABMPR1BTRIM24 | |
| SCHEMBL16038502 | 0.78 | ACVRL1 (0.43) | ACVRL1ACVR1BMPR1ABMPR1BTRIM24 | |
| SCHEMBL8264145 | 0.77 | FYN (0.48) | ACVRL1ACVR1BMPR1ABMPR1BTRIM24 | |
| SCHEMBL22643366 | 0.76 | TRIM24 (0.42) | ACVRL1ACVR1BMPR1ABMPR1BTRIM24 | |
| SCHEMBL15869577 | 0.76 | ACVRL1 (0.51) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL12045381 | 0.75 | ACVRL1 (0.43) | ACVRL1ACVR1BMPR1ABMPR1BTRIM24 | |
| SCHEMBL21234046 | 0.75 | ASIC3 (0.43) | ACVRL1ACVR1BMPR1ABMPR1BTRIM24 | |
| SCHEMBL15869576 | 0.74 | ACVRL1 (0.50) | ACVRL1ACVR1BMPR1ABMPR1BTGFBR1 | |
| SCHEMBL19155004 | 0.74 | CHRM1 (0.48) | ACVRL1ACVR1BMPR1ABMPR1BTRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542274-B1 | Therapeutic compounds and methods of use thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2023-01-03 | — | — | US | disclosed |
| US-11542274-B1 | Therapeutic compounds and methods of use thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2023-01-03 | — | — | US | disclosed |
| CN-114929670-A | Therapeutic compounds and methods of use thereof | 新加坡科技研究局 | 2022-08-19 | — | — | CN | disclosed |
| EP-4034526-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | Agency for Science, Technology and Research (A*STAR) (SG) | 2022-08-03 | — | — | EP | disclosed |
| US-20210147441-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2021-05-20 | — | — | US | disclosed |
| US-20210147441-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2021-05-20 | — | — | US | disclosed |
| WO-2021061053-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2021-04-01 | — | — | WO | disclosed |
| WO-2021061053-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2021-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147441-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | UBQLN2, TXNRD1, TXNRD2 | ACVRL1 4875/4885ACVR1 4850/4885BMPR1A 4251/4885 |
| US-11542274-B1 | Therapeutic compounds and methods of use thereof | MDM2, SUMO2, XIAP | ACVRL1 4569/4885ACVR1 4434/4885BMPR1A 3024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.