Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ICMT | O60725 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548029 | 0.85 | POLB (0.78) | POLBMAPTRECQLSMN1; SMN2LMNA | |
| SCHEMBL10195746 | 0.81 | MEN1 (0.69) | POLBMAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL14238826 | 0.78 | POLB (0.88) | POLBRECQLSMN1; SMN2LMNAMEN1 | |
| SCHEMBL6707299 | 0.77 | HSD11B1 (0.71) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL8265281 | 0.76 | CHKA (0.64) | POLBICMTLMNACYP2D6CYP2C19 | |
| SCHEMBL12087753 | 0.75 | ABCC4 (0.67) | LMNAMEN1KMT2A | |
| SCHEMBL9860301 | 0.75 | WNT3A (0.49) | ICMTLMNAMEN1KMT2AHDAC6 | |
| SCHEMBL7121816 | 0.75 | MEN1 (0.78) | POLBMAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL2376378 | 0.74 | SMN1; SMN2 (0.71) | POLBMAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL4548020 | 0.74 | POLB (0.69) | POLBMAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177518-A1 | Organic compounds | Novartis AG (CH) | 2010-04-21 | — | — | EP | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |