Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 2/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.52 |
| ▸ | TNKS | O95271 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264198 | 0.92 | LSS (0.71) | LSSESR1ESR2ACHEHRH3 | |
| SCHEMBL8264812 | 0.89 | CHRNB2 (0.59) | ESR1ESR2LTA4HKEAP1NFE2L2 | |
| SCHEMBL22831331 | 0.83 | LSS (0.83) | LSSESR1ESR2LTA4HKEAP1 | |
| SCHEMBL7442897 | 0.83 | CHRNB2 (0.69) | LSSESR1ESR2LTA4HKEAP1 | |
| SCHEMBL8264152 | 0.82 | FFAR4 (0.50) | LSSALDH1A1 | |
| SCHEMBL8265107 | 0.82 | CYP3A4 (0.47) | LSSLTA4HCHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL24721056 | 0.82 | LSS (0.56) | LSSESR1ESR2LTA4HKEAP1 | |
| SCHEMBL8360713 | 0.82 | CHRNB2 (0.67) | ESR1LTA4HKEAP1NFE2L2CHRNB2 | |
| SCHEMBL8264819 | 0.81 | MAOB (0.58) | LSSESR1CHRNB2CHRNA4MAOB | |
| SCHEMBL8264189 | 0.81 | TAAR1 (0.48) | LSSLTA4HMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177518-A1 | Organic compounds | Novartis AG (CH) | 2010-04-21 | — | — | EP | disclosed |
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |