Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 4/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29893681 | 0.86 | ACHE (0.50) | RPS6KA3CNR2CNR1AKR1C3AKR1C2 | |
| SCHEMBL2411804 | 0.82 | CNR2 (0.58) | CNR2CNR1CA12CA9ACHE | |
| SCHEMBL29360255 | 0.82 | CNR2 (0.58) | CNR2CNR1CA12CA9ACHE | |
| SCHEMBL30522728 | 0.81 | CA12 (0.51) | RPS6KA3CNR2CNR1CA12CA9 | |
| SCHEMBL1007613 | 0.81 | CA12 (0.51) | RPS6KA3CNR2CNR1CA12CA9 | |
| SCHEMBL9742510 | 0.81 | ALOX15 (0.50) | RPS6KA3CNR2CNR1AKR1C2CA12 | |
| SCHEMBL17037056 | 0.81 | ACHE (0.45) | RPS6KA3CNR2CNR1AKR1C3AKR1C2 | |
| SCHEMBL4527011 | 0.81 | RPS6KA3 (0.45) | RPS6KA3AKR1C3AKR1C2ACHEPDK2 | |
| SCHEMBL30522729 | 0.81 | CA12 (0.51) | RPS6KA3CNR2CNR1CA12CA9 | |
| SCHEMBL20721787 | 0.79 | CNR2 (0.51) | RPS6KA3CNR2CNR1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177518-A1 | Organic compounds | Novartis AG (CH) | 2010-04-21 | — | — | EP | disclosed |
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |