Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8261724 | 0.79 | CYP2C9 (0.40) | HTTPARP1PARP2CYP2D6CYP2C9 | |
| SCHEMBL8265470 | 0.78 | L3MBTL1 (0.37) | HTTPARP1PARP2CYP2D6CYP2C9 | |
| SCHEMBL8006237 | 0.75 | OPRL1 (0.33) | HTTPARP1PARP2CYP2D6CYP2C9 | |
| SCHEMBL8264212 | 0.75 | L3MBTL1 (0.35) | CYP2D6CYP2C9CYP2C19RENALDH1A1 | |
| SCHEMBL8265922 | 0.70 | LMNA (0.38) | HTTCYP2D6CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL8264308 | 0.68 | ALDH1A1 (0.35) | CYP2D6CYP2C9CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL14572801 | 0.66 | CYP2D6 (0.43) | HTTPARP1PARP2CYP2D6CYP2C9 | |
| SCHEMBL7999343 | 0.64 | CYP2D6 (0.32) | HTTPARP1PARP2CYP2D6CYP2C9 | |
| SCHEMBL16685237 | 0.64 | HTR2C (0.38) | CACNA1GCACNA1HCACNA1I | |
| SCHEMBL27668930 | 0.64 | SCN9A (0.34) | SCN9AALDH1A1DRD2HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |