Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | GAPDH | P04406 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28032593 | 0.89 | LMNA (0.66) | LMNACYP3A4MAOBACHEGAA | |
| SCHEMBL30638434 | 0.89 | LMNA (1.00) | LMNACYP3A4MAOBACHEGAA | |
| SCHEMBL280618 | 0.89 | LMNA (1.00) | LMNACYP3A4MAOBACHEGAA | |
| SCHEMBL28743154 | 0.88 | LMNA (0.66) | LMNACYP3A4MAOBACHEGAA | |
| SCHEMBL13680438 | 0.88 | LMNA (0.67) | LMNACYP3A4MAOBGAAMAPT | |
| SCHEMBL27808339 | 0.87 | LMNA (0.96) | LMNACYP3A4MAOBACHEGAA | |
| SCHEMBL27808382 | 0.87 | LMNA (0.96) | LMNACYP3A4MAOBACHEGAA | |
| Ammonia Solution, Strong SCHEMBL27920738 | 0.87 | LMNA (0.96) | LMNACYP3A4MAOBACHEGAA | |
| SCHEMBL4446422 | 0.85 | MAPT (0.67) | LMNACYP3A4ACHEGAAMAPT | |
| SCHEMBL4607313 | 0.84 | LMNA (0.71) | LMNACYP3A4ACHEGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177518-A1 | Organic compounds | Novartis AG (CH) | 2010-04-21 | — | — | EP | disclosed |
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |