Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264641 | 0.88 | LMNA (0.79) | LMNAGAAMAPTTDP1MEN1 | |
| SCHEMBL4960001 | 0.87 | LMNA (0.71) | LMNAGAAMAPTTDP1MEN1 | |
| SCHEMBL4607313 | 0.86 | LMNA (0.71) | LMNAGAAMAPTTDP1MEN1 | |
| SCHEMBL13680495 | 0.85 | MEN1 (0.52) | LMNAGAAMAPTTDP1MEN1 | |
| SCHEMBL28743154 | 0.83 | LMNA (0.66) | LMNAGAAMAPTTDP1MEN1 | |
| SCHEMBL23734827 | 0.83 | LMNA (0.67) | LMNAGAAMAPTTDP1MEN1 | |
| SCHEMBL8470717 | 0.83 | LMNA (0.67) | LMNAGAAMAPTTDP1HPGD | |
| SCHEMBL13680508 | 0.82 | RAB9A (0.59) | LMNAGAAMEN1KMT2APPARG | |
| SCHEMBL13680464 | 0.82 | ALDH1A1 (0.48) | LMNAGAAMAPTMEN1KMT2A | |
| SCHEMBL8469479 | 0.81 | LMNA (0.65) | LMNAGAAMAPTTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |