Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | GAPDH | P04406 | 1/20 | 0.54 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | RXRB | P28702 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28032593 | 0.94 | LMNA (0.66) | LMNAGAAMAPTTDP1CYP3A4 | |
| SCHEMBL8469858 | 0.91 | LMNA (0.60) | LMNAGAAMAPTTDP1CYP3A4 | |
| SCHEMBL8469479 | 0.91 | LMNA (0.65) | LMNAGAAMAPTTDP1HSD17B10 | |
| SCHEMBL4446422 | 0.91 | MAPT (0.67) | LMNAGAAMAPTTDP1CYP3A4 | |
| SCHEMBL4960001 | 0.90 | LMNA (0.71) | LMNAGAAMAPTTDP1CYP3A4 | |
| SCHEMBL8523753 | 0.89 | CYP3A4 (0.66) | LMNAGAAMAPTTDP1CYP3A4 | |
| SCHEMBL28743154 | 0.89 | LMNA (0.66) | LMNAGAAMAPTTDP1CYP3A4 | |
| SCHEMBL3781402 | 0.88 | LMNA (0.56) | LMNAGAAMAPTTDP1CYP3A4 | |
| SCHEMBL4436159 | 0.87 | LMNA (0.58) | LMNAGAAMAPTTDP1HPGD | |
| SCHEMBL23734827 | 0.86 | LMNA (0.67) | LMNAGAAMAPTTDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641773-B1 | PROCESS FOR PREPARING RALOXIFENE HYDROCHLORIDE | ERREGIERRE SPA (IT) | 2008-07-23 | — | — | EP | claimed |
| WO-1999025707-A1 | 2-ARYLBENZO[b]THIOPHENES USEFUL FOR THE TREATMENT OF ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 1999-05-27 | — | — | WO | claimed |
| WO-1999025707-A1 | 2-ARYLBENZO[b]THIOPHENES USEFUL FOR THE TREATMENT OF ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 1999-05-27 | — | — | WO | disclosed |
| US-5512684-A | Process for preparing 3-(4-aminoethoxy-benzoyl) benzo B!-thiophenes | ELI LILLY AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| US-4985589-A | (1S-cis)-3-(4-hydroxyphenyl),5-cyclohexadiene-1,2-diol and corresponding acetate | GENERAL ELECTRIC COMPANY (US) | 1991-01-15 | — | — | US | disclosed |
| US-4981793-A | Biological and chemical method for hydroxylating 4-substituted biphenyls and products obtained therefrom | GENERAL ELECTRIC COMPANY (US) | 1991-01-01 | — | — | US | disclosed |