Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 3/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | PLD2 | O14939 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.39 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22170856 | 0.78 | NPY5R (0.61) | NPY5RGBA1GHSRMTNR1AMTNR1B | |
| SCHEMBL17551505 | 0.77 | NPY5R (0.59) | NPY5RGBA1GHSREPHX2MTNR1A | |
| SCHEMBL12190609 | 0.76 | NPY5R (0.45) | NPY5RGBA1GHSREPHX2DRD3 | |
| SCHEMBL6359841 | 0.76 | PKM (0.53) | DRD3NAMPTNAAAKDM4EALDH1A1 | |
| SCHEMBL1193891 | 0.73 | NPY5R (0.54) | NPY5RGBA1GHSREPHX2MTNR1A | |
| SCHEMBL1193950 | 0.73 | GBA1 (0.53) | NPY5RGBA1GHSREPHX2DRD3 | |
| SCHEMBL8265142 | 0.72 | HPGD (0.73) | KDM4EALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL9083616 | 0.70 | GRIN2B (0.56) | NPY5RKDM4EALDH1A1 | |
| SCHEMBL6360425 | 0.70 | CHRNB2 (0.46) | GHSRDRD3MTNR1AMTNR1BNAMPT | |
| SCHEMBL15948326 | 0.70 | L3MBTL1 (0.49) | NPY5RDRD3DRD2GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838304-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORP (US) | 2009-08-19 | — | — | EP | disclosed |