Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264452 | 0.77 | TP53 (0.43) | POLBFPR2PROKR1TRPA1P2RX7 | |
| SCHEMBL10184808 | 0.77 | ABL1 (0.46) | POLBFPR2PROKR1TRPA1P2RX7 | |
| SCHEMBL1566944 | 0.74 | MAPT (0.57) | POLBFPR2PROKR1TRPA1MEN1 | |
| SCHEMBL7790025 | 0.74 | TRPA1 (0.47) | POLBFPR2PROKR1TRPA1MEN1 | |
| SCHEMBL3517848 | 0.73 | MAPT (0.59) | POLBFPR2PROKR1TRPA1MEN1 | |
| SCHEMBL9008342 | 0.73 | KMT2A (0.59) | TRPA1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7784547 | 0.73 | MAPT (0.59) | POLBFPR2PROKR1TRPA1MEN1 | |
| SCHEMBL31453688 | 0.73 | KMT2A (0.59) | TRPA1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8263943 | 0.73 | MAPK1 (0.48) | POLBMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL89147 | 0.72 | POLB (0.60) | POLBP2RX7MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177518-A1 | Organic compounds | Novartis AG (CH) | 2010-04-21 | — | — | EP | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |