Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11923244 | 0.82 | HSD17B10 (0.48) | TACR1HSD17B10POLBSMN1; SMN2PTPN11 | |
| SCHEMBL11923231 | 0.81 | TACR1 (0.42) | TACR1HSD17B10SMN1; SMN2 | |
| SCHEMBL8267812 | 0.80 | TACR1 (0.42) | TACR1HSD17B10POLBSMN1; SMN2THRB | |
| SCHEMBL8266485 | 0.78 | TACR1 (0.37) | TACR1HSD17B10POLBSMN1; SMN2PTPN11 | |
| SCHEMBL13199216 | 0.78 | TACR1 (0.42) | TACR1HSD17B10POLBTHRB | |
| SCHEMBL8266167 | 0.78 | TACR1 (0.44) | TACR1HSD17B10POLBSMN1; SMN2THRB | |
| SCHEMBL8267891 | 0.78 | HSD17B10 (0.30) | HSD17B10 | |
| SCHEMBL2961003 | 0.76 | WDR5 (0.43) | TACR1HSD17B10 | |
| SCHEMBL2952189 | 0.76 | THRB (0.48) | TACR1HSD17B10PTPN11THRB | |
| Hydrochloric Acid SCHEMBL2960113 | 0.75 | THRB (0.47) | TACR1HSD17B10PTPN11THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050476-A2 | PYRIMIDINE DERIVATIVES AS ION CHANNEL MODULATORS AND METHODS OF USE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-11 | — | — | WO | disclosed |