Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8271275 | 0.86 | RAB9A (0.39) | RAB9ANPC1POLBCHRM5CHRM1 | |
| SCHEMBL8269823 | 0.82 | TDP1 (0.41) | RAB9AMAPTMMEHTR2AOPRM1 | |
| SCHEMBL8270265 | 0.79 | MME (0.67) | RAB9ANPC1POLBCHRM5CHRM1 | |
| SCHEMBL9670805 | 0.78 | FFAR4 (0.55) | RAB9ANPC1POLBCHRM5CHRM1 | |
| SCHEMBL6337481 | 0.77 | MME (0.68) | RAB9ANPC1POLBCHRM5CHRM1 | |
| SCHEMBL6339711 | 0.77 | MME (0.68) | RAB9ANPC1POLBCHRM5CHRM1 | |
| SCHEMBL8269279 | 0.77 | MME (0.57) | RAB9ANPC1MMETSHR | |
| SCHEMBL81136 | 0.75 | FABP4 (0.58) | RAB9ANPC1POLBCHRM5CHRM1 | |
| SCHEMBL8270495 | 0.74 | MME (0.54) | RAB9ANPC1POLBCHRM5CHRM1 | |
| SCHEMBL24826094 | 0.72 | CTNNB1 (0.52) | RAB9ANPC1POLBFFAR4FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027680-A1 | 3-(1-CARBAMOYLCYCLOHEXYL) PROPIONIC ACID DERIVATIVES AS INHIBITORS OF NEUTRAL ENDOPEPTIDASE ENZYME | PFIZER LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |