Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8269841 | 0.83 | PSEN1 (0.40) | HTR1A | |
| SCHEMBL13513834 | 0.80 | HTR1A (0.33) | HTR1A | |
| SCHEMBL8268685 | 0.71 | FFAR1 (0.31) | — | |
| SCHEMBL18383142 | 0.68 | OPRM1 (0.47) | HTR1AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL3247360 | 0.61 | CYP2D6 (0.40) | HTR1AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL13921344 | 0.61 | OPRK1 (0.42) | HTR1AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL3247358 | 0.61 | CYP2D6 (0.40) | HTR1AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL12859443 | 0.60 | CYP2D6 (0.70) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL649311 | 0.59 | CYP2D6 (0.44) | HTR1AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL650751 | 0.59 | CYP2D6 (0.44) | HTR1AOPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006043064-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |