Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 6/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8272848 | 0.92 | PKM (0.44) | MAPTTHRBHCRTR1HCRTR2PKM | |
| SCHEMBL8272193 | 0.85 | FDFT1 (0.47) | TP53MAPTTHRBPKMALDH1A1 | |
| SCHEMBL3250468 | 0.84 | PKM (0.57) | HCRTR1HCRTR2PKMALDH1A1MCOLN3 | |
| SCHEMBL8275041 | 0.83 | KEAP1 (0.38) | TP53MAPTTHRBHCRTR2ALDH1A1 | |
| SCHEMBL8272847 | 0.82 | FDFT1 (0.41) | PKMFDFT1KEAP1NFE2L2 | |
| SCHEMBL3252908 | 0.80 | FDFT1 (0.47) | TP53MAPTTHRBHCRTR1HCRTR2 | |
| SCHEMBL3253770 | 0.79 | THRB (0.50) | TP53MAPTTHRBALDH1A1MCOLN3 | |
| SCHEMBL3255566 | 0.78 | PKM (0.59) | HCRTR1HCRTR2PKMALDH1A1MCOLN3 | |
| SCHEMBL8272192 | 0.78 | FDFT1 (0.40) | FDFT1 | |
| SCHEMBL3250958 | 0.77 | PKM (0.57) | HCRTR1HCRTR2PKMALDH1A1MCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006024779-A1 | SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2006-03-09 | — | — | WO | disclosed |