Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | EIF4E | P06730 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273584 | 0.88 | NAMPT (0.37) | ADAM17CYP2D6CYP3A4NAMPTUSP2 | |
| SCHEMBL8221040 | 0.88 | ADAM17 (0.54) | ADAM17CYP1A2CYP2D6CYP3A4NAMPT | |
| SCHEMBL8274406 | 0.82 | ADAM17 (0.49) | ADAM17ADAM10MMP12MMP13MEN1 | |
| SCHEMBL8213705 | 0.80 | ADAM17 (0.45) | ADAM17CYP2D6CYP3A4NAMPTUSP2 | |
| SCHEMBL8273582 | 0.80 | ADAM17 (0.47) | ADAM17NAMPTADAM10MMP12MMP13 | |
| SCHEMBL8273741 | 0.78 | ADAM17 (0.48) | ADAM17MEN1USP2GAAKMT2A | |
| SCHEMBL8275453 | 0.78 | ADAM17 (0.44) | ADAM17ADAM10MMP12MMP13MEN1 | |
| SCHEMBL8275600 | 0.75 | ADAM17 (0.45) | ADAM17NAMPTADAM10MMP12MMP13 | |
| SCHEMBL8273588 | 0.75 | ADAM17 (0.40) | ADAM17MEN1GAAKMT2AEIF4E | |
| SCHEMBL8273443 | 0.75 | DPP4 (0.41) | ADAM17MEN1GAAKMT2AHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |