Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
| ▸ | HRAS | P01112 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213677 | 0.88 | ADAM17 (0.48) | DPP4DPP7ADAM17DPP8DPP9 | |
| SCHEMBL8273584 | 0.88 | NAMPT (0.37) | ADAM17ALDH1A1HTTGAAL3MBTL1 | |
| SCHEMBL8273591 | 0.87 | ADAM17 (0.43) | DPP4DPP7ADAM17KCNH2ALDH1A1 | |
| SCHEMBL8273310 | 0.87 | GAA (0.44) | DPP4DPP7ADAM17KCNH2ALDH1A1 | |
| SCHEMBL8273592 | 0.86 | HTT (0.46) | DPP4DPP7ADAM17KCNH2ALDH1A1 | |
| SCHEMBL8273578 | 0.86 | ADAM17 (0.39) | DPP4ADAM17ALDH1A1HTTGAA | |
| SCHEMBL8273579 | 0.85 | CTSS (0.41) | ADAM17ALDH1A1HTTGAAKDM4E | |
| SCHEMBL8273588 | 0.85 | ADAM17 (0.40) | ADAM17ALDH1A1HTTGAAPDE6D | |
| SCHEMBL8273311 | 0.84 | ADAM17 (0.41) | ADAM17ALDH1A1HTTGAAL3MBTL1 | |
| SCHEMBL8274407 | 0.84 | ADAM17 (0.43) | DPP4DPP7ADAM17DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |