Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.33 |
| ▸ | DPP4 | P27487 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13544574 | 0.87 | NAMPT (0.43) | ADAM17DPP8HTR1ADRD2 | |
| SCHEMBL8275322 | 0.86 | ADAM17 (0.38) | ADAM17ADRA2CDPP7DPP8DPP9 | |
| SCHEMBL8275185 | 0.78 | ADAM17 (0.43) | ADAM17ADRA2CDPP7DPP8DPP9 | |
| SCHEMBL8275482 | 0.78 | ADAM17 (0.38) | ADAM17ADRA2CDPP7DPP8DPP9 | |
| SCHEMBL8273738 | 0.71 | ADAM17 (0.45) | ADAM17HTR1ADRD2ADAM10MMP12 | |
| SCHEMBL8275600 | 0.70 | ADAM17 (0.45) | ADAM17DPP7DPP8DPP9DPP4 | |
| SCHEMBL8274430 | 0.70 | ADAM17 (0.49) | ADAM17ADAM10MMP12MMP13 | |
| SCHEMBL8273361 | 0.69 | ADAM17 (0.54) | ADAM17DPP7DPP8DPP9DPP4 | |
| SCHEMBL8273441 | 0.69 | ADAM17 (0.54) | ADAM17DPP7DPP8DPP9DPP4 | |
| SCHEMBL8274845 | 0.69 | ADAM17 (0.44) | ADAM17HTR1ADRD2ADAM10MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |