Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.45 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8274845 | 0.87 | ADAM17 (0.44) | ADAM17ADAM10MMP12MMP13ALDH1A1 | |
| SCHEMBL8213511 | 0.87 | ADAM17 (0.43) | ADAM17ADAM10MMP12MMP13NAMPT | |
| SCHEMBL8273743 | 0.81 | ADAM17 (0.46) | ADAM17ADAM10MMP12MMP13ALDH1A1 | |
| SCHEMBL8275947 | 0.78 | ADAM17 (0.47) | ADAM17ADAM10MMP12MMP13ALDH1A1 | |
| SCHEMBL8275185 | 0.78 | ADAM17 (0.43) | ADAM17ADAM10MMP12MMP13NAMPT | |
| SCHEMBL8223420 | 0.76 | ADAM17 (0.43) | ADAM17ADAM10MMP12MMP13ALDH1A1 | |
| SCHEMBL8213906 | 0.73 | ADAM17 (0.48) | ADAM17ADAM10MMP12MMP13ALDH1A1 | |
| SCHEMBL8275918 | 0.72 | NAMPT (0.41) | ADAM17ALDH1A1NAMPTHTR1ADRD2 | |
| SCHEMBL8220887 | 0.72 | PRMT5 (0.33) | NAMPTHTR1ADRD2 | |
| SCHEMBL8273446 | 0.71 | ADAM17 (0.38) | ADAM17ADAM10MMP12MMP13HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |