Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.34 |
| ▸ | DPP4 | P27487 | 3/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8217853 | 0.87 | NAMPT (0.43) | ADAM17SCN9AHTR1A | |
| SCHEMBL16357103 | 0.87 | NAMPT (0.43) | ADAM17SCN9AHTR1A | |
| SCHEMBL8274427 | 0.84 | ADAM17 (0.37) | ADAM17SCN9ADPP7DPP8DPP4 | |
| SCHEMBL8273448 | 0.78 | TSHR (0.40) | SCN9AMEN1GAAKMT2A | |
| SCHEMBL8273446 | 0.78 | ADAM17 (0.38) | ADAM17DPP7DPP8DPP4DPP9 | |
| SCHEMBL8275185 | 0.77 | ADAM17 (0.43) | ADAM17DPP7DPP8DPP4DPP9 | |
| SCHEMBL8275322 | 0.76 | ADAM17 (0.38) | ADAM17DPP7DPP8DPP4DPP9 | |
| SCHEMBL8275600 | 0.72 | ADAM17 (0.45) | ADAM17DPP7DPP8DPP4DPP9 | |
| SCHEMBL8273441 | 0.70 | ADAM17 (0.54) | ADAM17DPP7DPP8DPP4DPP9 | |
| SCHEMBL8273361 | 0.70 | ADAM17 (0.54) | ADAM17DPP7DPP8DPP4DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |