Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273578 | 0.91 | ADAM17 (0.39) | ADAM17HTTALDH1A1GAAKDM4E | |
| SCHEMBL8222728 | 0.89 | ADAM17 (0.49) | ADAM17RPS6KB1SCN5ASCN9ACHRM4 | |
| SCHEMBL8273310 | 0.89 | GAA (0.44) | ADAM17HTTALDH1A1GAAKDM4E | |
| SCHEMBL8273591 | 0.89 | ADAM17 (0.43) | ADAM17HTTALDH1A1GAAKDM4E | |
| SCHEMBL8273592 | 0.88 | HTT (0.46) | ADAM17HTTALDH1A1GAAKDM4E | |
| SCHEMBL8273582 | 0.88 | ADAM17 (0.47) | ADAM17GAAKDM4EHDAC3HDAC1 | |
| SCHEMBL8273579 | 0.86 | CTSS (0.41) | ADAM17HTTALDH1A1GAAKDM4E | |
| SCHEMBL8273588 | 0.86 | ADAM17 (0.40) | ADAM17HTTALDH1A1GAAKDM4E | |
| SCHEMBL8274407 | 0.85 | ADAM17 (0.43) | ADAM17HTTALDH1A1GAAL3MBTL1 | |
| SCHEMBL8276118 | 0.85 | ADAM17 (0.43) | ADAM17HTTALDH1A1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |