Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 9/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273743 | 0.90 | ADAM17 (0.46) | ADAM17NAMPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8276637 | 0.85 | ADAM17 (0.53) | ADAM17NAMPTALDH1A1MTNR1AMTNR1B | |
| SCHEMBL8276994 | 0.85 | NAMPT (0.49) | ADAM17NAMPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8217374 | 0.85 | ADAM17 (0.45) | ADAM17NAMPTMTNR1AMTNR1BMEN1 | |
| SCHEMBL8275946 | 0.83 | NAMPT (0.41) | NAMPTALDH1A1HPGDSMN1; SMN2MTNR1A | |
| SCHEMBL8213993 | 0.81 | ADAM17 (0.47) | ADAM17NAMPTALDH1A1MEN1KMT2A | |
| SCHEMBL8275600 | 0.80 | ADAM17 (0.45) | ADAM17NAMPTMEN1KMT2AADAM10 | |
| SCHEMBL8273738 | 0.78 | ADAM17 (0.45) | ADAM17NAMPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8213991 | 0.78 | ADAM17 (0.55) | ADAM17NAMPTALDH1A1MEN1KMT2A | |
| SCHEMBL13544350 | 0.78 | ADAM17 (0.47) | ADAM17NAMPTMEN1KMT2AADAM10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |