Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.50 |
| ▸ | SELE | P16581 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12505384 | 0.90 | STK39 (0.51) | PTGER4MRGPRX4CTNNB1ICAM1SELE | |
| SCHEMBL12505440 | 0.89 | CTNNB1 (0.65) | MRGPRX4CTNNB1LMNAL3MBTL1BRD4 | |
| SCHEMBL29250434 | 0.88 | L3MBTL1 (0.63) | PTGER4MRGPRX4CTNNB1LMNAL3MBTL1 | |
| SCHEMBL30974584 | 0.88 | L3MBTL1 (0.63) | PTGER4MRGPRX4CTNNB1LMNAL3MBTL1 | |
| SCHEMBL30974621 | 0.88 | CTNNB1 (0.68) | CTNNB1ICAM1SELEVCAM1LMNA | |
| SCHEMBL29251269 | 0.88 | CTNNB1 (0.68) | CTNNB1ICAM1SELEVCAM1LMNA | |
| SCHEMBL30974617 | 0.87 | CTNNB1 (0.51) | PTGER4MRGPRX4CTNNB1LMNAL3MBTL1 | |
| SCHEMBL29251268 | 0.87 | CTNNB1 (0.51) | PTGER4MRGPRX4CTNNB1LMNAL3MBTL1 | |
| SCHEMBL4445314 | 0.86 | MRGPRX4 (0.60) | PTGER4MRGPRX4LMNAL3MBTL1CYP1A2 | |
| SCHEMBL4450385 | 0.82 | PTGER4 (0.56) | PTGER4MRGPRX4LMNAL3MBTL1EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005102389-A9 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2009-04-30 | — | — | WO | disclosed |