Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 8/20 | 0.45 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8222066 | 0.85 | CHRM4 (0.45) | ADAM17ADAM10MMP12MMP13GAA | |
| SCHEMBL13544350 | 0.84 | ADAM17 (0.47) | ADAM17ADAM10MMP12MMP13KMT2A | |
| SCHEMBL8274406 | 0.79 | ADAM17 (0.49) | ADAM17ADAM10MMP12MMP13KMT2A | |
| SCHEMBL8273582 | 0.77 | ADAM17 (0.47) | ADAM17ADAM10MMP12MMP13KMT2A | |
| SCHEMBL8221362 | 0.75 | ADAM17 (0.66) | ADAM17ADAM10MMP12MMP13ALDH1A1 | |
| SCHEMBL13544358 | 0.74 | ADAM17 (0.49) | ADAM17ADAM10MMP12MMP13KMT2A | |
| SCHEMBL8221461 | 0.74 | ADAM17 (0.60) | ADAM17ADAM10MMP12MMP13ALDH1A1 | |
| SCHEMBL8273765 | 0.74 | ADAM17 (0.43) | ADAM17KMT2AMEN1 | |
| SCHEMBL14494381 | 0.74 | ADAM17 (0.43) | ADAM17KMT2AMEN1 | |
| SCHEMBL8273743 | 0.73 | ADAM17 (0.46) | ADAM17ADAM10MMP12MMP13KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |