Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.35 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8274446 | 0.89 | ADAM17 (0.43) | HDAC1HDAC2DPP8DPP4DPP9 | |
| SCHEMBL8222795 | 0.89 | ADAM17 (0.43) | HDAC1HDAC2DPP8DPP4DPP9 | |
| SCHEMBL8224737 | 0.84 | CHRM4 (0.41) | DPP8ADAM17 | |
| SCHEMBL8276118 | 0.82 | ADAM17 (0.43) | DPP8DPP4DPP9DPP7ADAM17 | |
| SCHEMBL8274407 | 0.82 | ADAM17 (0.43) | DPP8DPP4DPP9DPP7ADAM17 | |
| SCHEMBL8273591 | 0.82 | ADAM17 (0.43) | HDAC1HDAC2DPP4DPP7ADAM17 | |
| SCHEMBL8273310 | 0.82 | GAA (0.44) | DPP4DPP7ADAM17ALDH1A1L3MBTL1 | |
| SCHEMBL8275981 | 0.81 | NAMPT (0.42) | DPP8DPP9ADAM17ALDH1A1L3MBTL1 | |
| SCHEMBL8273592 | 0.81 | HTT (0.46) | DPP4DPP7ADAM17ALDH1A1L3MBTL1 | |
| SCHEMBL8273768 | 0.81 | HPGDS (0.38) | HDAC1HDAC2DPP8DPP4DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652020-B2 | novel hydantoin derivatives to inhibit matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs) and/or tumor necrosis factor alpha converting enzyme (TACE) and in so doing prevent the release of tumor necrosis factor alpha (TNF- alpha ); autoimmune diseases; side effect reduction | SCHERING CORPORATION (US) | 2010-01-26 | — | — | US | disclosed |
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |