Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.41 |
| ▸ | NAMPT | P43490 | 6/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275760 | 0.94 | ADAM17 (0.48) | ADAM17FFAR4CHRM4NAMPTSCN5A | |
| SCHEMBL8213656 | 0.92 | ADAM17 (0.54) | ADAM17FFAR4CHRM4NAMPTSCN5A | |
| SCHEMBL8222661 | 0.85 | ADAM17 (0.53) | ADAM17FFAR4CHRM4SCN5ASCN9A | |
| SCHEMBL8274846 | 0.81 | ADAM17 (0.61) | ADAM17CHRM4NAMPTMEN1KMT2A | |
| SCHEMBL8273353 | 0.81 | ADAM17 (0.61) | ADAM17CHRM4NAMPTMEN1KMT2A | |
| SCHEMBL8275183 | 0.78 | ADAM17 (0.43) | ADAM17NAMPTSCN5ASCN9AMEN1 | |
| SCHEMBL8213653 | 0.78 | CHRM4 (0.49) | ADAM17CHRM4 | |
| SCHEMBL14494381 | 0.77 | ADAM17 (0.43) | ADAM17CHRM4NAMPTSCN5ASCN9A | |
| SCHEMBL8273765 | 0.77 | ADAM17 (0.43) | ADAM17CHRM4NAMPTSCN5ASCN9A | |
| SCHEMBL8221026 | 0.77 | ADAM17 (0.51) | ADAM17CHRM4NAMPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |