Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | LOX | P28300 | 3/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | LOXL3 | P58215 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13920471 | 0.87 | LOXL2 (0.51) | LOXL2VNN1PDK2L3MBTL3L3MBTL1 | |
| SCHEMBL13920470 | 0.87 | LOXL2 (0.51) | LOXL2VNN1PDK2L3MBTL3L3MBTL1 | |
| SCHEMBL13920475 | 0.84 | MRGPRX4 (0.51) | LOXL2VNN1L3MBTL1LOXLOXL3 | |
| SCHEMBL8275304 | 0.83 | GRM5 (0.56) | L3MBTL3L3MBTL1ALDH1A1HPGD | |
| SCHEMBL17850465 | 0.83 | ALDH1A1 (0.48) | TLR2TLR1ALDH1A1HPGDPLA2G1B | |
| SCHEMBL15172210 | 0.82 | GAA (0.62) | LOXL2ALDH1A1HPGDPLA2G1BATG4B | |
| SCHEMBL7903359 | 0.80 | CA12 (0.51) | PDK2L3MBTL3L3MBTL1ALDH1A1HPGD | |
| SCHEMBL28202826 | 0.80 | NPC1 (0.53) | TLR2TLR1ALDH1A1HPGDPLA2G1B | |
| SCHEMBL8274181 | 0.79 | TLR2 (0.39) | TLR2TLR1VNN1PDK2L3MBTL3 | |
| SCHEMBL18765947 | 0.79 | HPGD (0.62) | L3MBTL3L3MBTL1ALDH1A1HPGDKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758883-B1 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORP (US) | 2011-11-02 | — | — | EP | disclosed |
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511062-B2 | Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| WO-2005116009-A1 | SUBSTITUTED 2-QUINOLYL-OXAZOLES USEFUL AS PDE4 INHIBITORS | SCHERING CORPORATION (US) | 2005-12-08 | — | — | WO | disclosed |