Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 2/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275305 | 0.87 | GRM5 (0.47) | HSD11B1ALDH1A1HPGDMAPTGRM3 | |
| SCHEMBL12163055 | 0.85 | MRGPRX4 (0.49) | VNN1MRGPRX4PDK2ALDH1A1NPC1 | |
| SCHEMBL8275216 | 0.83 | HPGD (0.53) | ALDH1A1HPGDNPC1MAPTRAB9A | |
| SCHEMBL8275217 | 0.81 | ALDH1A1 (0.48) | HSD11B1ALDH1A1HPGDNPC1MAPT | |
| SCHEMBL12162954 | 0.81 | ALDH1A1 (0.48) | HSD11B1ALDH1A1HPGDNPC1MAPT | |
| SCHEMBL8274693 | 0.79 | HDAC3 (0.44) | TLR2TLR1VNN1PDK2CHRNB2 | |
| SCHEMBL8275193 | 0.77 | RORC (0.34) | — | |
| SCHEMBL12162956 | 0.76 | LOXL2 (0.50) | VNN1MRGPRX4PDK2HPGDNPC1 | |
| SCHEMBL17850465 | 0.73 | ALDH1A1 (0.48) | TLR2TLR1ALDH1A1HPGDMAPT | |
| SCHEMBL8275220 | 0.72 | MRGPRX4 (0.36) | MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005116009-A1 | SUBSTITUTED 2-QUINOLYL-OXAZOLES USEFUL AS PDE4 INHIBITORS | SCHERING CORPORATION (US) | 2005-12-08 | — | — | WO | disclosed |