Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 9/20 | 0.62 |
| ▸ | NOS3 | P29474 | 5/20 | 0.53 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.39 |
| ▸ | PDCD1LG2 | Q9BQ51 | 5/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275938 | 0.90 | NOS1 (0.61) | NOS1NOS3IDH1KDM4EALDH1A1 | |
| SCHEMBL8275836 | 0.86 | NOS1 (0.65) | NOS1NOS3IDH1KDM4EALDH1A1 | |
| SCHEMBL8275994 | 0.84 | NOS1 (0.69) | NOS1NOS3KDM4EALDH1A1CD274 | |
| SCHEMBL8275984 | 0.84 | NOS1 (0.62) | NOS1NOS3KDM4EALDH1A1CD274 | |
| SCHEMBL8275900 | 0.83 | NOS1 (0.61) | NOS1NOS3IDH1KDM4EALDH1A1 | |
| SCHEMBL8275903 | 0.82 | NOS1 (0.60) | NOS1NOS3KDM4EALDH1A1CD274 | |
| SCHEMBL8275853 | 0.82 | NOS1 (0.60) | NOS1NOS3ALDH1A1CD274PDCD1LG2 | |
| SCHEMBL8275915 | 0.82 | NOS1 (0.60) | NOS1NOS3CD274PDCD1LG2HTR2A | |
| SCHEMBL8275863 | 0.82 | NOS1 (0.60) | NOS1NOS3CD274PDCD1LG2 | |
| SCHEMBL8275862 | 0.82 | NOS1 (0.73) | NOS1NOS3CD274PDCD1LG2PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2004-04-22 | — | — | US | disclosed |
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | NOS3, NOS1, NOS2 | NOS1 2/4885NOS3 1/4885IDH1 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.