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SCHEMBL8276969

SCHEMBL8276969

NC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CP(=O)(O)C(Cc1ccccc1)NC(=O)OCc1ccccc1

nearest known ligand 0.72

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 15/20 0.70
▸ MMP9 P14780 15/20 0.70
▸ MMP8 P22894 15/20 0.70
▸ MMP14 P50281 15/20 0.70
▸ MMP11 P24347 3/20 0.70
▸ MMP7 P09237 3/20 0.69
▸ MME P08473 3/20 0.69
▸ ACE P12821 1/20 0.69
▸ ECE1 P42892 2/20 0.64
▸ MMP13 P45452 4/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6274298 1.00 MMP2 (0.70) MMP2MMP9MMP8MMP14MMP11
SCHEMBL6274299 0.88 MMP2 (0.61) MMP2MMP9MMP8MMP14MMP11
SCHEMBL5399966 0.85 NMBR (0.71) MMP2MMP9MMP8MMP14MMP11
SCHEMBL5556658 0.83 NMBR (0.74) MMP2MMP9MMP8MMP14MMP11
SCHEMBL5381814 0.80 NMBR (0.73) MMP2MMP9MMP8MMP14MMP11
SCHEMBL29472048 0.80 NMBR (0.73) MMP2MMP9MMP8MMP14MMP11
SCHEMBL1711383 0.80 NMBR (0.73) MMP2MMP9MMP8MMP14MMP11
SCHEMBL31326046 0.78 NMBR (0.74) MMEACEECE1
SCHEMBL6270839 0.77 MMP2 (0.60) MMP2MMP9MMP8MMP14MMP11
SCHEMBL6281455 0.77 MMP2 (0.60) MMP2MMP9MMP8MMP14MMP11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005105843-A2 HIV PROTEASE INHIBITORS ARPIDA A/S (DK) 2005-11-10 — — WO disclosed