SCHEMBL6274299

NC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CP(=O)(O)CC(NC(=O)OCc1ccccc1)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	MMP2	P08253	17/20	0.61

▸	MMP9	P14780	17/20	0.61

▸	MMP14	P50281	17/20	0.61

▸	MMP8	P22894	16/20	0.61

▸	MMP7	P09237	3/20	0.60

▸	MMP11	P24347	2/20	0.59

▸	MME	P08473	1/20	0.59

▸	ACE	P12821	1/20	0.59

▸	ANPEP	P15144	1/20	0.55

▸	ERAP1	Q9NZ08	1/20	0.55

▸	MMP13	P45452	1/20	0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8276969	0.88	MMP2 (0.70)	MMP2MMP9MMP14MMP8MMP7
SCHEMBL6274298	0.88	MMP2 (0.70)	MMP2MMP9MMP14MMP8MMP7
SCHEMBL5399966	0.83	NMBR (0.71)	MMP2MMP9MMP14MMP8MMP7
SCHEMBL5556658	0.81	NMBR (0.74)	MMP2MMP9MMP14MMP8MMP7
SCHEMBL29472048	0.78	NMBR (0.73)	MMP2MMP9MMP14MMP8MMP7
SCHEMBL5381814	0.78	NMBR (0.73)	MMP2MMP9MMP14MMP8MMP7
SCHEMBL1711383	0.78	NMBR (0.73)	MMP2MMP9MMP14MMP8MMP7
SCHEMBL31326046	0.76	NMBR (0.74)	MMEACE
SCHEMBL5379426	0.75	MMP2 (0.66)	MMP2MMP9MMP14MMP8MMP7
SCHEMBL5383412	0.75	BMP1 (0.65)	MMP2MMP9MMP14MMP8MMP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2005105843-A2	HIV PROTEASE INHIBITORS	ARPIDA A/S (DK)	2005-11-10	—	—	WO	claimed
WO-2005105843-A2	HIV PROTEASE INHIBITORS	ARPIDA A/S (DK)	2005-11-10	—	—	WO	disclosed