Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | IFNAR1 | P17181 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12819940 | 0.80 | CYP2A6 (0.47) | CYP2A6CYP2B6CYP2E1OPRL1PTPRC | |
| SCHEMBL30340124 | 0.80 | CYP2A6 (0.47) | CYP2A6CYP2B6CYP2E1OPRL1PTPRC | |
| SCHEMBL15525017 | 0.78 | SLC6A2 (0.49) | CYP2A6CYP2B6CYP2E1OPRL1PTPRC | |
| SCHEMBL417693 | 0.77 | LTA4H (0.55) | LTA4HPRMT6CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL28754758 | 0.77 | CYP2A6 (0.48) | PRMT6CYP2A6CYP2B6CYP2E1PTPRC | |
| SCHEMBL22548895 | 0.77 | CYP2A6 (0.44) | PRMT6CYP2A6CYP2B6CYP2E1PTPRC | |
| SCHEMBL21480391 | 0.77 | CYP2A6 (0.47) | CYP2A6CYP2B6CYP2E1PTPRCBCHE | |
| SCHEMBL477489 | 0.77 | CYP2A6 (0.47) | CYP2A6CYP2B6CYP2E1PTPRCKIT | |
| SCHEMBL7502553 | 0.77 | CYP2A6 (0.47) | CYP2A6CYP2B6CYP2E1PTPRCBCHE | |
| SCHEMBL3181212 | 0.77 | CYP2A6 (0.47) | CYP2A6CYP2B6CYP2E1PTPRCBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005090354-A1 | PYRAZOLO[3,4-b] PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |