SCHEMBL8280980

SCHEMBL8280980

COCc1nnc(-c2ccc(OC(C)C)cn2)n1-c1ccc(OC)nc1

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
OXTR P30559 20/20 0.63
AVPR1A P37288 17/20 0.63
AVPR2 P30518 4/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6531349 0.89 OXTR (0.48) OXTRAVPR1AAVPR2
SCHEMBL8282035 0.84 OXTR (0.69) OXTRAVPR1AAVPR2
SCHEMBL931537 0.83 OXTR (0.68) OXTRAVPR1AAVPR2
SCHEMBL931562 0.78 OXTR (0.74) OXTRAVPR1AAVPR2
SCHEMBL6513251 0.77 OXTR (0.68) OXTRAVPR1AAVPR2
SCHEMBL6508499 0.76 OXTR (0.55) OXTRAVPR1AAVPR2
SCHEMBL930550 0.76 OXTR (0.80) OXTRAVPR1AAVPR2
SCHEMBL931497 0.75 OXTR (0.68) OXTRAVPR1AAVPR2
SCHEMBL931371 0.75 OXTR (1.00) OXTRAVPR1AAVPR2
SCHEMBL8282006 0.74 OXTR (0.72) OXTRAVPR1AAVPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005082866-A2 SUBSTITUTED 1, 2, 4- TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS PFIZER LIMITED (GB) 2005-09-09 WO disclosed